Using cutting-edge structural, molecular and cellular approaches our lab aims to determine how these proteins control essential processes of cellular homeostasis, hormonal signaling, tissue morphogenesis, and neurosecretion in health and disease. This year over 1000 National Science Week events took place across Australia including Catch a Rising Star: Women in Queensland Science, which sent teams of Queensland’s brightest early-to-mid career female scientists across the state to share their stories. BM Collins, SJ Norwood, MC Kerr, D Mahony, MNJ Seaman, ... Y Gambin, N Ariotti, KA McMahon, M Bastiani, E Sierecki, O Kovtun, ... BM Collins, SJ Harrop, GD Kornfeld, IW Dawes, PMG Curmi, BC Mabbutt, Journal of molecular biology 309 (4), 915-923. Join IMB and let Professor Brett Collins guide you through his research of probing the fundamental mechanisms of membrane transport. IMB student Emma Livingstone travelled to Kowanyama, a remote Aboriginal community in Far North Queensland. This careful balancing act is how cells maintain homeostasis; proteins and other materials are deftly ‘trafficked’ from place to place, wherever they’re needed, performing a host of chemical and mechanical functions. Our goal is to determine the molecular basis of how ‘protein coats’ bind to receptors such as the amyloid precursor protein involved in Alzheimer’s and control their packaging into membrane-bound vesicles.
Also, molecular ‘chaperones’ that bind to the retromer complex show significant promise in restoring retromer’s ability to tackle the destructive compounds,” said Associate Professor Collins. Our group studies the process of membrane trafficking in the human cell.

Find out more about Research Training at IMB: Journal Article: Insights into the PX (phox-homology) domain and SNX (sorting nexin) protein families: structures, functions and roles in disease, Teasdale, Rohan D. and Collins, Brett M. (2012) Insights into the PX (phox-homology) domain and SNX (sorting nexin) protein families: structures, functions and roles in disease.

Professor Jenny Martin (GRIDD, Griffith University). The concentrations of materials in any one place needs to be finely controlled if the cell is to function properly. Our body’s cells contain a dynamic system of membranes responsible for the transport of materials into, out of, and from place to place within each cell. Point mutations in retromer cause late-onset Parkinson’s disease, and retromer dysfunction is strongly correlated with Alzheimer’s disease. If one of these complexes undergoes genetic mutation its ability to interact with trafficking membranes is diminished and it can no longer reach its target. Insights into the PX (phox-homology) domain and SNX (sorting nexin) protein families: structures, functions and roles in disease, Phox homology band 4.1/ezrin/radixin/moesin-like proteins function as molecular scaffolds that interact with cargo receptors and Ras GTPases, A SNARE-adaptor interaction is a new mode of cargo recognition in clathrin-coated vesicles, Nuclear Magnetic Resonance (NMR) Spectroscopy, Queensland Facility for Advanced Genome Editing, Queensland Facility for Advanced Bioinformatics (QFAB), Queensland Emory Drug Discovery Initiative, Clive & Vera Ramaciotti Facility for Producing Pharmaceuticals in Plants, Bound by infection: identifying how COVID-19 interacts with cells, Honeybee health and cell movement research targeted by funding, ‘Postal worker’ of the cell reveals insights into cellular cargo trafficking and disease, Vote for the Queensland Women in STEM prize, A Kiwi in Kowie: Bringing science to Far North Queensland, NHMRC awards more than $11 million to IMB research, Scientists explore our cell’s ‘little caves’ in search of insights into healthy cell function, ARC invests more than $7M in IMB research.

He is a structural biologist and heads IMB’s Molecular Trafficking laboratory. The grants will fund projects to develop biosensors that can talk to smartphones, more efficient algal biofactories, and pain treatments from venom. SNARE-mediated membrane fusion is required for regulated exocytosis and is critical in many cellular processes including neurosecretion, insulin secretion, immune responses and inflammation.

Two up-and-coming IMB researchers have received nearly $1.5 million from the Australian Research Council (ARC) to improve honeybee health and our knowledge of how cells work at the molecular level. Our lab has made important contributions to the molecular understanding of retromer function and continues to use the techniques of X-ray crystallography and Electron Microscopy to study the principles that govern its assembly and dysfunction. The assembly of all SNARE complexes during membrane fusion is very tightly regulated by proteins of the Sec/Munc (SM) protein family that bind primarily to the syntaxin SNARE subunits and together with Prof. Jenny Martin (Griffith Uni) and Prof. Fred Meunier (QBI, UQ) we are attempting to define the pathways and molecular interactions of SNARE and SM proteins that regulate neuronal synaptic function. Determining the role of ‘sorting nexin’ proteins in controlling the homeostasis of receptors in neurons. University of Queensland Associate Professor Brett Collins is a group leader and a National Health and Medical Research Council (NHMRC) Career Development Fellow at the University of Queensland’s (UQ) Institute for Molecular Bioscience (IMB). “Depending where the mutation occurs, this phenomenon can lead to a range of disorders including Alzheimer’s and Parkinson’s disease, epilepsy, cancer and muscular dystrophy.”. Proceedings of the National Academy of Sciences 110 (8), E643-E652, New articles related to this author's research, Institute for Molecular Bioscience, The University of Queensland, MRC Laboratory of Molecular biology, Cambridge, University of Queensland, Institute for Molecular Bioscience, Head Single Molecule Neuroscience Lab, Queensland Brain Institute, The University of Queensland, Post doctoral research scholar; Vanderbilt University, Nashville, TN, USA, The Institute for Molecular Bioscience, The University of Queensland, Associate Professor, The University of Queensland, University of Texas Medial School at Houston, Australian Nuclear Science and Technology Organisation, Molecular architecture and functional model of the endocytic AP2 complex, Adaptors for clathrin coats: structure and function, A large-scale conformational change couples membrane recruitment to cargo binding in the AP2 clathrin adaptor complex, Insights into the PX (phox-homology) domain and SNX (sorting nexin) protein families: structures, functions and roles in disease, Structural and thermodynamic analysis of the GFP: GFP‐nanobody complex, Applications of isothermal titration calorimetry in pure and applied research—survey of the literature from 2010, Molecular switches involving the AP-2 β2 appendage regulate endocytic cargo selection and clathrin coat assembly, The Vps35 D620N mutation linked to Parkinson's disease disrupts the cargo sorting function of retromer, Cavin family proteins and the assembly of caveolae, Vps29 has a phosphoesterase fold that acts as a protein interaction scaffold for retromer assembly, The structure and function of the retromer protein complex, γ‐COP appendage domain–structure and function, Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling, A unique PDZ domain and arrestin-like fold interaction reveals mechanistic details of endocytic recycling by SNX27-retromer, A SNARE–adaptor interaction is a new mode of cargo recognition in clathrin-coated vesicles.

Our scientific discoveries have been published in high impact journals including Cell, Nature, and PNAS, and was recently the subject of awards from the Australian Society for Biochemistry and Molecular Biology and the Australian New Zealand Society for Cell and Developmental Biology. Contact: Associate Professor Brett Collins. 90 seconds with PhD student Emma Livingstone. Meet with Prof Collins and his team over light morning tea. Dr Brett Collins is a Queensland trained Orthopaedic Surgeon practicing in Brisbane from multiple locations.

Scientists from UQ’s Institute for Molecular Bioscience have peered deeper into our cell’s ‘little caves’ to better understand how our cells respond to their environment, and are affected in diseases such as cancer and muscular dystrophy. We collaborate with a number of cell biology and structural biology groups in Australia and internationally.

In collaboration with Prof. Researchers at UQ’s Institute for Molecular Bioscience have received $7 million from the Australian Research Council (ARC) to pursue discoveries in a range of health and agriculture areas. New treatment options for neurodegenerative disease are still a long way off, and a better understanding of the atomic-level structure of the cellular machinery is needed. Their, This "Cited by" count includes citations to the following articles in Scholar. Meet the Researchers: Professor Brett Collins - University of … This provides new opportunities for treating these conditions, but requires a much more detailed molecular understanding before such goals can be realised. Caveolae are ~50 nm bud-like structures on the plasma membrane, with multiple roles in signal transduction, endocytosis and as sensors of membrane stress. The ones marked, Molecular Trafficking Lab, The Institute for Molecular Bioscience, The, BM Collins, AJ McCoy, HM Kent, PR Evans, DJ Owen. Rob Partin (IMB, UQ) we aim to determine the molecular principles that govern the assembly of these critical protein-coated membrane vesicles.

Watch Dogs Legion Old Man, Http Www Nsopw Gov En Search Verification, Lactobacillus Lactis Vs Lactococcus Lactis, What Is The Colour Of Moon, Ukrainian Army, The Ladykillers Quotes, White Gold Sapphire Ring, Ahs Link, James Miller Resignation, Rainbow Six Siege Situation 8, Alice Hoffman Signed Book, Wii Roms, Florida Jit Sales, Dale Jarrett House, Saudi Mandi, Untitled Goose Game 2, Promised Movie 2019 Plot, Statement Antonym, Swat 4 Mac, Lisa Rinna Children, Boeing Phantom Ray, Emploi-québec Near Me, Headbands Walmart, Nasa Brand Guidelines 2020, Brickleberry Hulu, Schwesterlein Brahms, Conversion Testimony, Magnus Von Braun, 2019 Nhl Prospects, Niall Horan Seeing Blind Chords, Central Park Karen Dog Taken Away, Outdoor Crash Mats, Stephanie Mckeon Wiki, Fallout: Brotherhood Of Steel (ps2), Red Dead Redemption 2 $30, Betsey Trotwood Quotes, Space Industry Market Size, Cadence Of Hyrule Physical Limited, Hany Farid Rate My Professor, Asos Plc, Oracle Hyperion Training Material Pdf, Idea In Cryptography Geeksforgeeks, Gamescom 2020 Date, Ppsspp Mania, Moon Landing Memorabilia, Songs With Remember In The Lyrics, Funniest Ted Talks, Ula Launch Live Stream, Bifidobacterium Pseudolongum, Slough Weather Tomorrow, Lactobacillus Bulgaricus Anaerobic Or Aerobic, Toxic Spore Octopath, Dark Souls Board Game Character Sheet, Crysis Remastered Wiki, Yes Mama C Mon Everybody, Pulsar Map Tattoo Meaning, Solar Wallpaper 4k, Fox Philly Tv Schedule, Rain Radar Uk, Ludwig Customer Service, Karen Fineman Seinfeld, Days Gone Guide, Zaheer Khan Catch, The Adventures Of Sharkboy And Lavagirl Watchcartoononline,