DES daughters have an increased risk of developing abnormal cells in the cervix and the vagina that are precursors of cancer (dysplasia, cervical intraepithelial neoplasia, and squamous intraepithelial lesions) (6). Some pharmacies keep records for a long time and can be contacted regarding prescription dispensing information. Titus-Ernstoff L, Troisi R, Hatch EE, et al.

Sato K, Fukata H, Kogo Y, et al. Although the risk of developing testicular cancer among DES-exposed sons is unclear, males with undescended or unusually small testicles have an increased risk of testicular cancer whether or not they were exposed to DES. Epidemiology 2008; 19(2):251–257.

Journal of Rheumatology 2010; 37(10):2167–2173. It was prescribed to pregnant women between 1940 and 1971 to prevent miscarriage, premature labor, and related complications of pregnancy (1). Some studies suggest that the increased risk of infertility is mainly due to uterine or fallopian tube problems (9).

Offspring of women exposed to diethylstilbestrol (DES): a preliminary report of benign and malignant pathology in the third generation.
However, some doctors believe that DES daughters should avoid these medications because they contain estrogen (21). DES daughters have more than twice the risk of early menopause (menopause that begins before age 45) as unexposed women. A thorough examination may include the following: Pap test and colposcopy—A routine cervical Pap test is not adequate for DES daughters. The cancer risks for exposed sons are also being studied to determine whether they differ from those for unexposed men.

Prenatal diethylstilbestrol exposure and risk of breast cancer. Titus-Ernstoff L, Troisi R, Hatch EE, et al. DES daughters should be aware of these health risks, share their medical history with their doctors, and get regular physical examinations. Adenocarcinoma of the vagina. Epidemiology 2003; 14(2):155–160.

Autoimmune disease incidence among women prenatally exposed to diethylstilbestrol.

Antenatal exposure to DES: lessons learned…future concerns.

What is the cancer risk of women who were exposed to DES before birth? Stay up to date on the latest developments in Internet terminology with a free newsletter from Webopedia. Diethylstilbestrol (DES) is a synthetic form of the female hormone estrogen.

Also see Triple DES. It has been recommended that exposed women have an annual medical examination to check for the adverse health effects of DES (6).

Titus-Ernstoff L, Hatch EE, Hoover RN, et al. Herbst AL, Ulfelder H, Poskanzer DC. The county medical society or health department may know where the records have been stored. Long-term cancer risk in women given diethylstilbestrol (DES) during pregnancy.

Birth defects in the sons and daughters of women who were exposed in utero to diethylstilbestrol (DES). Resources for people who were exposed to DES include the following: National Cancer Institute O’Reilly EJ, Mirzaei F, Forman MR, Ascherio A. Diethylstilbestrol exposure in utero and depression in women. Women who think they used DES during pregnancy, or people who think that their mother used DES during pregnancy, can try contacting the physician or institution where they received their care to request a review of their medical records. Read More », Networking fundamentals teaches the building blocks of modern network design. Fertility and Sterility 1999; 72(1):1–7. No evidence exists to suggest that women who took DES are at higher risk for any other type of cancer (4). Complementary & Alternative Medicine (CAM), Coping with Your Feelings During Advanced Cancer, Emotional Support for Young People with Cancer, Young People Facing End-of-Life Care Decisions, Late Effects of Childhood Cancer Treatment, Tech Transfer & Small Business Partnerships, Frederick National Laboratory for Cancer Research, Milestones in Cancer Research and Discovery, Step 1: Application Development & Submission, U.S. Department of Health and Human Services. Participants were initially drawn from eight different medical centers and consisted of five individual cohorts of people.

Palmer JR, Herbst AL, Noller KL, et al. Short for Data Encryption Standard, a popular symmetric-key encryption method developed in 1975 and standardized by ANSI in 1981 as ANSI X.3.92.

However, this association is based on small numbers of events and was not statistically significant. However, a 2010 study from Europe found no difference in breast cancer risk between DES daughters and unexposed women and no difference in overall cancer risk (5). Rubin MM.

Hoover RN, Hyer M, Pfeiffer RM, et al. Military medical records are kept for 25 years.

Association with vaginal and cervical cancers and other abnormalities. Annals of Internal Medicine 1995; 122(10):778–788. Professional and Public Relations Committee of the DESAD (Diethylstilbestrol and Adenosis) Project of the Division of Cancer Control and Rehabilitation. Adverse health outcomes in women exposed in utero to diethylstilbestrol.

However, because each of these associations is based on small numbers of events, researchers will continue to study these groups to clarify the findings.

International Journal of Epidemiology 2006; 35(4):862–868. Soon after, the Food and Drug Administration (FDA) notified physicians throughout the country that DES should not be prescribed to pregnant women (3). Titus-Ernstoff L, Troisi R, Hatch EE, et al.
The Registry for Research on Hormonal Transplacental Carcinogenesis (also called the Clear Cell Cancer Registry) is a worldwide registry for individuals diagnosed with clear cell adenocarcinoma of the vagina and/or cervix. These groups are called DES granddaughters and DES grandsons, or the third generation.

Scientists estimate that 3% of DES-exposed women have experienced early menopause due to their exposure to DES (7). The University of Chicago However, research thus far suggests that DES daughters do not have an increased risk of autoimmune diseases.

Verloop J, van Leeuwen FE, Helmerhorst TJ, van Boven HH, Rookus MA. Staff members also answer questions from the public. One study found a 40% increase in risk of depression, whereas another found no increased risk for these women (11, 12). Researchers are also studying possible health effects among women and men who are the children of DES daughters. Lancet 2002; 359(9312):1102–1107. A 2011 study found that about 2% of a large cohort of DES daughters has developed breast cancer due to their exposure (7). Whether DES-exposed sons have increased risks of testicular or prostate cancer is unclear; studies to date have produced mixed results. Studies have not shown that hormone replacement therapy is unsafe for DES daughters.

DES is now known to be an endocrine-disrupting chemical, one of a number of substances that interfere with the endocrine system to cause cancer, birth defects, and other developmental abnormalities. What health problems might women who took DES during pregnancy have? An analysis of updated data published in 2011 is outlined in the table below.

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